|
KMID : 0361120160300020059
|
|
Korean Journal of Transplantation
2016 Volume.30 No. 2 p.59 ~ p.68
|
|
|
Genetic Polymorphism in Proteins of the Complement System
|
|
Kim Hyo-Ri
Hwang Do-Been
Han Jung-Won
Lee Hwa-Kyoung
Yang Won-Jun
Jin Jun-Yeong
Kim Ki-Hyun
Kim Sang-Il
Yoo Duck-Kyun
Kim Soo-Hyun
Chung Jun-Ho
|
|
|
Abstract
|
|
|
|
The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.
|
|
|
KEYWORD
|
|
|
Complement system proteins, Genetic polymorphism, Autoimmune diseases
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|